without it, a cell becomes dysfunctional and eventually undergoes apoptosis if the stressor is not ameliorated [211]
Small molecules such as RSL3 and erastin, which primarily target GPX4 and SLC7A11, respectively, demonstrate that impairment of cystine uptake or lipid peroxide detoxification is sufficient to directly trigger ferroptotic cell death
Connection to Stem Cell and Regenerative Medicine Research Areas: Glutathione is a major focus in Regenerative Medicine
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